{"product_id":"new-product-700938","title":"CD35\/CR1 Rabbit pAb","description":"\u003cp\u003eThis gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence\/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and\/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":48576948404504,"sku":"A10059","price":298.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/new-product-700938","provider":"Dana Bioscience","version":"1.0","type":"link"}