{"product_id":"new-product-700437","title":"BCR Rabbit pAb","description":"\u003cp\u003eA reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine\/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"Abclonal","offers":[{"title":"100ul","offer_id":48576718700824,"sku":"A0068","price":298.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/new-product-700437","provider":"Dana Bioscience","version":"1.0","type":"link"}