{"product_id":"new-product-651614","title":"Polyclonal Antibody to Cyclin D1 (CCND1)","description":"\u003cp\u003eWestern blotting: 0.2-2µg\/mL;1:250-2500 \u003cbr\u003e Immunohistochemistry: 5-20µg\/mL;1:25-100 \u003cbr\u003e Immunocytochemistry: 5-20µg\/mL;1:25-100 \u003cbr\u003e Optimal working dilutions must be determined by end user.\u003c\/p\u003e\n\u003cp\u003eProduct No.\u003c\/p\u003e\n\u003cp\u003ePAA585Bo01\u003c\/p\u003e\n\u003cp\u003eOrganism Species\u003c\/p\u003e\n\u003cp\u003eBos taurus; Bovine (Cattle).\u003c\/p\u003e\n\u003cp\u003eSource\u003c\/p\u003e\n\u003cp\u003ePolyclonal antibody preparation\u003c\/p\u003e\n\u003cp\u003eHost\u003c\/p\u003e\n\u003cp\u003eRabbit\u003c\/p\u003e\n\u003cp\u003ePotency\u003c\/p\u003e\n\u003cp\u003en\/a\u003c\/p\u003e\n\u003cp\u003eIg Type\u003c\/p\u003e\n\u003cp\u003eIgG\u003c\/p\u003e\n\u003cp\u003ePurification\u003c\/p\u003e\n\u003cp\u003eAntigen-specific affinity chromatography followed by Protein A affinity chromatography\u003c\/p\u003e\n\u003cp\u003eLabel\u003c\/p\u003e\n\u003cp\u003eNone\u003c\/p\u003e\n\u003cp\u003eImmunogen\u003c\/p\u003e\n\u003cp\u003en\/a\u003c\/p\u003e\n\u003cp\u003eBuffer Formulation\u003c\/p\u003e\n\u003cp\u003ePBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.\u003c\/p\u003e\n\u003cp\u003eTraits\u003c\/p\u003e\n\u003cp\u003eLiquid\u003c\/p\u003e\n\u003cp\u003eConcentration\u003c\/p\u003e\n\u003cp\u003e500µg\/mL\u003c\/p\u003e\n\u003cp\u003eOrganism Species More\u003c\/p\u003e\n\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\n\u003cp\u003eApplications\u003c\/p\u003e\n\u003cp\u003eWB; IHC; ICC; IP.\u003c\/p\u003e\n\u003cp\u003eIf the antibody is used in flow cytometry, please check FCM antibodies.\u003c\/p\u003e\n\u003cp\u003eUOM\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e20µl \u003c\/span\u003e\u003cspan\u003e100µl\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e200µl\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e1ml\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e10ml\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv class=\"product\"\u003e\n\u003cdiv class=\"product_left\"\u003e\n\u003ch3\u003eSPECIFITY\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe antibody is a rabbit polyclonal antibody raised against CCND1. It has been selected for its ability to recognize CCND1 in immunohistochemical staining and western blotting.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eUSAGE\u003c\/h3\u003e\n\u003cdiv class=\"img_parent\"\u003e\n\u003cp\u003eWestern blotting: 0.2-2µg\/mL;1:250-2500\u003cbr\u003eImmunohistochemistry: 5-20µg\/mL;1:25-100\u003cbr\u003eImmunocytochemistry: 5-20µg\/mL;1:25-100\u003cbr\u003eOptimal working dilutions must be determined by end user.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSTORAGE\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eStore at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSTABILITY\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product_reference\"\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr class=\"first_tr\"\u003e\n\u003ctd class=\"td_1\"\u003eMagazine\u003c\/td\u003e\n\u003ctd\u003eCitations\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBiochemical Pharmacology\u003c\/td\u003e\n\u003ctd\u003eAntiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006295211002097\" rel=\"nofollow\" target=\"_blank\"\u003eScienceDirect: S0006295211002097\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLeukemia \u0026amp; Lymphoma\u003c\/td\u003e\n\u003ctd\u003eThe nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-62 human leukemia cells\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24138332\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed: 24138332\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThe Journal of Clinical Endocrinology and Metabolism\u003c\/td\u003e\n\u003ctd\u003eAntiproliferative and proapoptotic activity of sunitinib on endothelial and anaplastic thyroid cancer cells via inhibition of Akt and ERK1\/2 phosphorylation and by down-regulation of cyclin-D1.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23969186\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed: 23969186\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNutrition and Cancer\u003c\/td\u003e\n\u003ctd\u003eCommon Food Additive Carrageenan Stimulates Wnt\/ β-Catenin Signaling in Colonic Epithelium by Inhibition of Nucleoredoxin Reduction\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24328990\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed:24328990\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eThe International Journal of Biochemistry \u0026amp; Cell Biology\u003c\/td\u003e\n\u003ctd\u003eMicroRNA-149 is epigenetically silenced tumor-suppressive microRNA, involved in cell proliferation and downregulation of AKT1 and cyclin D1 in human …\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27783537\" rel=\"nofollow\" target=\"_blank\"\u003epubmed:27783537\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eScientific Reports\u003c\/td\u003e\n\u003ctd\u003eIs there an association between enhanced choline and β-catenin pathway in breast cancer? A pilot study by MR Spectroscopy and ELISA.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28533512\" rel=\"nofollow\" target=\"_blank\"\u003epubmed:28533512\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInvestigational new drugs\u003c\/td\u003e\n\u003ctd\u003eDevelopment of a dietary formulation of the SHetA2 chemoprevention drug for mice.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29273857\" rel=\"nofollow\" target=\"_blank\"\u003epubmed:29273857\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBiochemical Pharmacology\u003c\/td\u003e\n\u003ctd\u003eMetronomic vinorelbine is directly active on Non Small Cell Lung Cancer cells and sensitizes the EGFRL858R\/T790M cells to reversible EGFR tyrosine kinase …\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29660315\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed:29660315\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eApoptosis\u003c\/td\u003e\n\u003ctd\u003eLicarin A induces cell death by activation of autophagy and apoptosis in non-small cell lung cancer cells\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29468481\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed:29468481\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOncology Reports\u003c\/td\u003e\n\u003ctd\u003eVandetanib has antineoplastic activity in anaplastic thyroid cancer, in vitro and in vivo\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29517106\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed:29517106\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOncology Reports\u003c\/td\u003e\n\u003ctd\u003eLenvatinib exhibits antineoplastic activity in anaplastic thyroid cancer in vitro and in vivo\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29517103\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed:29517103\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eScientific Reports\u003c\/td\u003e\n\u003ctd\u003eIs there an association between enhanced choline and β-catenin pathway in breast cancer? A pilot study by MR Spectroscopy and ELISA\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/cyberleninka.org\/article\/n\/804499\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed: 28533512\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMiddle East Journal of Rehabilitation and Health\u003c\/td\u003e\n\u003ctd\u003eAntiapoptotic Effects of Continuous Training and Selenium Consumption on the Liver Tissue of Cadmium-Exposed Rats\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/jrehabilhealth.com\/en\/articles\/91278.html\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed: 10.5812\/mejrh.91278\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEuropean journal of medicinal chemistry\u003c\/td\u003e\n\u003ctd\u003eSynthesis of novel S-linked dihydroartemisinin derivatives and evaluation of their anticancer activity\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0223523419305379\" rel=\"nofollow\" target=\"_blank\"\u003ePubmed: 31216504\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product_relation\"\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr class=\"first_tr\"\u003e\n\u003ctd class=\"td_1\"\u003eCatalog No.\u003c\/td\u003e\n\u003ctd class=\"td_2\"\u003eRelated products for research use of Bos taurus; Bovine (Cattle) Organism species\u003c\/td\u003e\n\u003ctd class=\"td_3\"\u003eApplications (RESEARCH USE ONLY!)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRPA585Bo01\u003c\/td\u003e\n\u003ctd\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/RPA585Bo01.html\"\u003eRecombinant Cyclin D1 (CCND1)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003ePositive Control; Immunogen; SDS-PAGE; WB.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePAA585Bo01\u003c\/td\u003e\n\u003ctd\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/PAA585Bo01.html\"\u003ePolyclonal Antibody to Cyclin D1 (CCND1)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003eWB; IHC; ICC; IP.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"more_info\"\u003e\u003c\/div\u003e","brand":"Cloud-clone","offers":[{"title":"200µl \/ 500µg\/mL \/ Bos taurus; Bovine (Cattle)","offer_id":47597363888408,"sku":"PAA585Bo01","price":378.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/PAA585Bo01-201708091121531376_f803a437-c990-4f98-8330-f5eb10105224.jpg?v=1706375869","url":"https:\/\/danabiosci.com\/products\/new-product-651614","provider":"Dana Bioscience","version":"1.0","type":"link"}