{"product_id":"new-product-622271","title":"Recombinant Tyrosine Hydroxylase (TH)","description":"\u003cp\u003eProkaryotic expression\u003c\/p\u003e\n\u003cp\u003eProduct No.\u003c\/p\u003e\n\u003cp\u003eRPB438Bo01\u003c\/p\u003e\n\u003cp\u003eOrganism Species\u003c\/p\u003e\n\u003cp\u003eBos taurus; Bovine (Cattle).\u003c\/p\u003e\n\u003cp\u003eSource\u003c\/p\u003e\n\u003cp\u003eProkaryotic expression\u003c\/p\u003e\n\u003cp\u003eHost\u003c\/p\u003e\n\u003cp\u003eE.coli\u003c\/p\u003e\n\u003cp\u003eEndotoxin Level\u003c\/p\u003e\n\u003cp\u003e\u0026lt;1.0EU per 1µg (determined by the LAL method)\u003c\/p\u003e\n\u003cp\u003eSubcellular Location\u003c\/p\u003e\n\u003cp\u003eSecreted\u003c\/p\u003e\n\u003cp\u003ePredicted Molecular Mass\u003c\/p\u003e\n\u003cp\u003e48.9kDa\u003c\/p\u003e\n\u003cp\u003eAccurate Molecular Mass\u003c\/p\u003e\n\u003cp\u003e49kDa(Analysis of differences refer to the manual)\u003c\/p\u003e\n\u003cp\u003eResidues \u0026amp; Tags\u003c\/p\u003e\n\u003cp\u003eAla45~Pro214 with N-terminal His and GST Tag\u003c\/p\u003e\n\u003cp\u003eBuffer Formulation\u003c\/p\u003e\n\u003cp\u003ePBS, pH7.4, containing 0.01% SKL, 5% Trehalose.\u003c\/p\u003e\n\u003cp\u003eTraits\u003c\/p\u003e\n\u003cp\u003eFreeze-dried powder\u003c\/p\u003e\n\u003cp\u003ePurity\u003c\/p\u003e\n\u003cp\u003e\u0026gt; 95%\u003c\/p\u003e\n\u003cp\u003eIsoelectric Point\u003c\/p\u003e\n\u003cp\u003e6.7\u003c\/p\u003e\n\u003cp\u003eApplications\u003c\/p\u003e\n\u003cp\u003ePositive Control; Immunogen; SDS-PAGE; WB.\u003c\/p\u003e\n\u003cp\u003eIf bio-activity of the protein is needed, please check active protein.\u003c\/p\u003e\n\u003cp\u003eUOM\u003c\/p\u003e\n\u003cp\u003e10µg 50µg 200µg 1mg 5mg\u003c\/p\u003e\n\u003ch3\u003eSEQUENCE\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"product_image\"\u003e\n\u003cimg src=\"https:\/\/www.cloud-clone.com\/upload\/product\/pictures\/RPB438Bo01-202303031007524544.jpg\"\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eUSAGE\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eReconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg\/mL. Do not vortex.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSTORAGE\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eAvoid repeated freeze\/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch3\u003eSTABILITY\u003c\/h3\u003e\n\u003cdiv\u003e\n\u003cp\u003eThe thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.\u003c\/p\u003e\n\u003cdiv class=\"product_reference\"\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr class=\"first_tr\"\u003e\n\u003ctd class=\"td_1\"\u003eMagazine\u003c\/td\u003e\n\u003ctd\u003eCitations\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMol Neurobiol.\u003c\/td\u003e\n\u003ctd\u003e1, 25-dyhydroxyvitamin D3 Attenuates l-DOPA-Induced Neurotoxicity in Neural Stem Cells\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25102940\" target=\"_blank\"\u003ePubmed:25102940\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePLOS ONE\u003c\/td\u003e\n\u003ctd\u003eGenetic Diagnosis of Two Dopa-Responsive Dystonia Families by Exome Sequencing\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25181484\" target=\"_blank\"\u003ePubmed:25181484\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ebiomedicine \u0026amp; pharmacotherapy\u003c\/td\u003e\n\u003ctd\u003eAcetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat.\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28199883\" target=\"_blank\"\u003epubmed:28199883\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTherapeutics and Clinical Risk Management\u003c\/td\u003e\n\u003ctd\u003eElevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in an Indian population.\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27540296\" target=\"_blank\"\u003epubmed:27540296\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSci Rep. \u003c\/td\u003e\n\u003ctd\u003eSilencing salusin-β attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats.\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28230187\" target=\"_blank\"\u003epubmed:28230187\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eJournal of Cellular Biochemistry\u003c\/td\u003e\n\u003ctd\u003eVaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28681939\" target=\"_blank\"\u003epubmed:28681939\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEnvironmental Science \u0026amp; Technology\u003c\/td\u003e\n\u003ctd\u003eMultigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29565584\" target=\"_blank\"\u003ePubmed:29565584\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular Neurobiology\u003c\/td\u003e\n\u003ctd\u003eCilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29429051\" target=\"_blank\"\u003ePubmed:29429051\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemosphere\u003c\/td\u003e\n\u003ctd\u003eTetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29407805\" target=\"_blank\"\u003ePubmed:29407805\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNeurospine\u003c\/td\u003e\n\u003ctd\u003eThe Effect of Recombinant Tyrosine Hydroxylase Expression on the Neurogenic Differentiation Potency of Mesenchymal Stem Cells\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29656620\" target=\"_blank\"\u003ePubmed:29656620\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eToxicology and Applied Pharmacology\u003c\/td\u003e\n\u003ctd\u003eMontelukast attenuates rotenone-induced microglial activation\/p38 MAPK expression in rats: Possible role of its antioxidant, anti-inflammatory and antiapoptotic effects\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0041008X18304186\" target=\"_blank\"\u003ePubmed: 30222980\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInternational Journal Of Cardiology\u003c\/td\u003e\n\u003ctd\u003eSilencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK\/NF-κB pathways in the paraventricular nucleus\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167527318356055\" target=\"_blank\"\u003ePubmed: 30581101\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBehavioural Brain Research\u003c\/td\u003e\n\u003ctd\u003eHydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition\u003ca rel=\"nofollow\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166432818315924\" target=\"_blank\"\u003e\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEnvironment International\u003c\/td\u003e\n\u003ctd\u003ePerfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31733528\/\" target=\"_blank\"\u003ePubmed: 31733528\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEnvironmental Pollution\u003c\/td\u003e\n\u003ctd\u003eEmbryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31935612\/\" target=\"_blank\"\u003ePubmed: 31935612\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInternational Journal of Pharmacology\u003c\/td\u003e\n\u003ctd\u003eNose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32084576\/\" target=\"_blank\"\u003ePubmed: 32084576\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ecomparative biochemistry and physiology c-toxicology \u0026amp; pharmacology\u003c\/td\u003e\n\u003ctd\u003eThyroid disruption and developmental toxicity caused by Cd2+ in Schizopygopsis younghusbandi larvae\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32344129\/\" target=\"_blank\"\u003ePubmed: 32344129\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eInternational Journal of Stem cell Research \u0026amp; Therapy\u003c\/td\u003e\n\u003ctd\u003eSelection of Cells for Parkinson's Disease Cell-Therapy\u003ca rel=\"nofollow\" href=\"https:\/\/pdfs.semanticscholar.org\/cfcf\/35c7e61cbea8858af0b59e5717968470e58b.pdf\" target=\"_blank\"\u003e\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEcotoxicol Environ Saf\u003c\/td\u003e\n\u003ctd\u003eEffects of SiO2 nanoparticles on the uptake of tetrabromobisphenol A and its impact on the thyroid endocrine system in zebrafish larvae\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33385677\" target=\"_blank\"\u003e33385677\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eNutr Res\u003c\/td\u003e\n\u003ctd\u003eTocotrienols protect differentiated SH-SY5Y human neuroblastoma cells against 6-hydroxydopamine-induced cytotoxicity by ameliorating dopamine biosynthesis and …\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35065349\/\" target=\"_blank\"\u003ePubmed:35065349\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFood Chem Toxicol\u003c\/td\u003e\n\u003ctd\u003eOmarigliptin attenuates rotenone-induced Parkinson's disease in rats: Possible role of oxidative stress, endoplasmic reticulum stress and immune modulation\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35439590\/\" target=\"_blank\"\u003ePubmed:35439590\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFood Chemistry: Molecular Sciences\u003c\/td\u003e\n\u003ctd\u003eUnravelling the neuroprotective mechanisms of carotenes in differentiated human neural cells: biochemical and proteomic approaches\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"nofollow\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35415676\/\" target=\"_blank\"\u003ePubmed:35415676\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eJournal of Environmental Sciences\u003c\/td\u003e\n\u003ctd\u003eParental and transgenerational impairments of thyroid endocrine system in zebrafish by 2, 4, 6-tribromophenol\u003ca rel=\"nofollow\" href=\"https:\/\/sciencedirect.53yu.com\/science\/article\/pii\/S1001074221003958\" target=\"_blank\"\u003e\u003c\/a\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product_relation\"\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr class=\"first_tr\"\u003e\n\u003ctd class=\"td_1\"\u003eCatalog No.\u003c\/td\u003e\n\u003ctd class=\"td_2\"\u003eRelated products for research use of Bos taurus; Bovine (Cattle) Organism species\u003c\/td\u003e\n\u003ctd class=\"td_3\"\u003eApplications (RESEARCH USE ONLY!)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRPB438Bo01\u003c\/td\u003e\n\u003ctd\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/RPB438Bo01.html\"\u003eRecombinant Tyrosine Hydroxylase (TH)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003ePositive Control; Immunogen; SDS-PAGE; WB.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePAB438Bo01\u003c\/td\u003e\n\u003ctd\u003e\u003ca href=\"https:\/\/www.cloud-clone.com\/products\/PAB438Bo01.html\"\u003ePolyclonal Antibody to Tyrosine Hydroxylase (TH)\u003c\/a\u003e\u003c\/td\u003e\n\u003ctd\u003eWB; IHC; ICC; IP.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Cloud-clone","offers":[{"title":"50ug \/ \u003e 95% \/ Bos taurus; Bovine (Cattle)","offer_id":47569585963288,"sku":"RPB438Bo01","price":478.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/NP_0419e995-3ffd-4857-84f2-8edd738f6b01.jpg?v=1705991436","url":"https:\/\/danabiosci.com\/products\/new-product-622271","provider":"Dana Bioscience","version":"1.0","type":"link"}