{"product_id":"new-product-603501","title":"anti- PNPT1 antibody","description":"\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePNPT1 antibody\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSize\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e100µg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eForm\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eliquid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmunogen affinity purified\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e≥95% as determined by SDS-PAGE\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRabbit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClonality\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003epolyclonal\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIgG\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze \/ thaw cycles.)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBACKGROUND\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome(mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing(MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain(ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1\/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIMMUNOGEN INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImmunogen\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003epolyribonucleotide nucleotidyltransferase 1\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePNPASE\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e90 kDa\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAPPLICATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTested Application\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eELISA, WB, IHC, IP\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended Dilution\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUNIPROT INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUniProt ID\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"http:\/\/www.uniprot.org\/uniprot\/Q8TCS8\"\u003eQ8TCS8\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003cimg data-mce-fragment=\"1\" src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image1\/FNab06593.jpg\" data-mce-src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image1\/FNab06593.jpg\"\u003e\u003c\/p\u003e\n\u003cdiv class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003eImmunohistochemistry of paraffin-embedded human gliomas using FNab06593(PNPT1 antibody) at dilution of 1:100\u003c\/div\u003e\n\u003cdiv class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003e\n\u003cimg src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image3\/FNab06593.jpg\"\u003e\n\u003cdiv class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003eIP Result of anti-PNPT1 (IP:FNab06593, 4ug; Detection:FNab06593 1:1000) with mouse brain tissue lysate 4000ug.\u003c\/div\u003e\n\u003cdiv class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003e\n\u003cimg src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image4\/FNab06593.jpg\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"content-area w-full py-4 lg:w-3\/4 lg:pr-4 lg:py-12\" id=\"primary\"\u003e\u003cmain data-mce-fragment=\"1\" class=\"site-main\" id=\"main\"\u003e\n\u003carticle data-mce-fragment=\"1\" class=\"post-19060 ft_product type-ft_product status-publish hentry product_host-rabbit product_clonality-polyclonal product_reactivity-human product_reactivity-mouse product_reactivity-rat product_tested_application-elisa product_tested_application-ihc product_tested_application-ip product_tested_application-wb ft_product_category-primary-antibody ft_research_area-epigenetics ft_research_area-metabolism\" id=\"post-19060\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"entry-details\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"product-tab-slider w-full mt-6\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"product-tab-slider--container\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"product-tab-slider--body\" id=\"specifications\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"content-block\"\u003e\n\u003cdl data-mce-fragment=\"1\" class=\"content-block--list\"\u003e\n\u003cdd data-mce-fragment=\"1\" class=\"one-column flex flex-wrap\"\u003e\n\u003cdiv data-mce-fragment=\"1\" class=\"w-full md:pl-8 pt-4 md:pt-0 md:w-1\/3\"\u003ehuman brain tissue were subjected to SDS PAGE followed by western blot with FNab06593(PNPT1 antibody) at dilution of 1:1500\u003c\/div\u003e\n\u003c\/dd\u003e\n\u003c\/dl\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/article\u003e\n\u003c\/main\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"w-full md:w-2\/3 p-2 border relative\"\u003e\u003c\/figure\u003e\n\u003c\/div\u003e\n\u003cfigure class=\"w-full md:w-2\/3 p-2 border relative\"\u003e\u003c\/figure\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"FineTest","offers":[{"title":"100µg","offer_id":47561190703384,"sku":"FNab06593","price":290.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/fine_test_logo_ef115b7b-b12a-4e4d-b90a-46f0870b7106.jpg?v=1705875623","url":"https:\/\/danabiosci.com\/products\/new-product-603501","provider":"Dana Bioscience","version":"1.0","type":"link"}