anti- GAD1 antibody

Uncover the intricate workings of brain function and inhibitory neurotransmission with our Anti-GAD1 Antibody, available in a 100µg size. GAD1 (Glutamate Decarboxylase 1) is a pivotal enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), playing a crucial role in neuronal signaling. This antibody is meticulously designed to specifically target GAD1, enabling you to study its functions with precision.

Key Features:

• Precise Targeting: Rigorously validated to exclusively recognize GAD1, reducing the risk of non-specific binding to other proteins.
• Versatile Applications: Suitable for various experimental techniques, including Western blotting, immunofluorescence, and immunoprecipitation, empowering your research in neurotransmission and brain function.
• Adequate Quantity: With 100µg of antibody, you have enough material for multiple experiments, reducing the need for frequent restocking.
• Quality Guaranteed: Manufactured under stringent quality control measures to ensure the consistency and reliability of your results.
• Explore Neurological Mechanisms: Whether you're investigating GAD1's role in psychiatric disorders, neurodevelopmental research, or neuronal excitability, our Anti-GAD1 Antibody is your trusted companion.

  Product Name

  GAD1 antibody

  Size

  100µg

  Form

  liquid

  Purification

  Immunogen affinity purified

  Purity

  ≥95% as determined by SDS-PAGE

  Host

  Rabbit

  Clonality

  polyclonal

  Isotype

  IgG

  Storage

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

  BACKGROUND

  This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

  IMMUNOGEN INFORMATION

  Immunogen

  glutamate decarboxylase 1

  Synonyms

  FLJ45882, GAD, GAD 67, GAD1, GAD67, Glutamate decarboxylase 1, SCP

  Observed MW

  67 kDa

  APPLICATION

  Tested Application

  ELISA, WB

  Recommended Dilution

  WB: 1:500 - 1:2000

  UNIPROT INFORMATION

  UniProt ID

  Q99259

  IMAGES

  

  Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09843( GAD1 Antibody) at dilution of 1:1000