anti- Caspase 1 antibody

Our Anti-Caspase 1 Antibody (Polyclonal, 100µg) is a versatile tool for researchers investigating inflammatory responses and pyroptosis, key components of the immune system. Caspase 1, also known as interleukin-1β-converting enzyme (ICE), is central to these processes, and our polyclonal antibody is tailored to detect Caspase 1 with precision.

Produced in a rabbit host, this antibody offers excellent sensitivity and specificity, making it ideal for various applications, including Western blotting, immunohistochemistry, and flow cytometry. Researchers can have confidence in the accuracy of their results when using our Anti-Caspase 1 Antibody.

With 100µg of antibody per vial, you'll have an abundant supply for multiple experiments, reducing the need for frequent reordering. The polyclonal nature of this antibody enhances its utility, allowing it to recognize multiple epitopes on the target protein, making it suitable for diverse experimental settings.

By using our Anti-Caspase 1 Antibody, you contribute to the advancement of knowledge in the fields of inflammation and immunity. Its high-quality performance ensures that your research progresses smoothly and reliably.

Product Name

Caspase 1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta(IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing.

IMMUNOGEN INFORMATION

Immunogen

caspase 1

Synonyms

CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45

Observed MW

45-47 kDa, 30 kDa, 35 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:50-1:500

UNIPROT INFORMATION

UniProt ID

P29466

IMAGES

Immunohistochemistry of paraffin-embedded human stomach tissue slide using FNab10015(CASP1 Antibody) at dilution of 1:100

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab10015(CASP1 antibody) at dilution of 1:1000