anti- CD14 antibody

Explore the diverse roles of CD14 in the immune system with our Anti-CD14 Polyclonal Antibody, available in a 100µg size. CD14, a vital glycoprotein found on immune cell surfaces, plays a pivotal role in recognizing and responding to bacterial lipopolysaccharides, initiating the innate immune response.

Derived from rabbit hosts, this polyclonal antibody offers exceptional sensitivity and versatility for a wide range of applications, including flow cytometry, immunohistochemistry, and immunoprecipitation. Its polyclonal nature allows for recognition of multiple epitopes, enhancing its utility in diverse research contexts.

With 100µg at your disposal, you have a generous supply for multiple experiments, reducing the need for frequent reordering and ensuring the continuity of your research.

Don't miss the opportunity to unravel the multifaceted functions of CD14 in immune response. With our Anti-CD14 Polyclonal Antibody, you can confidently delve into your research and uncover the secrets hidden within this critical immune receptor.

Product Name

CD14 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Coreceptor for bacterial lipopolysaccharide(PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide(LPS)(PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response(PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway(PubMed:16880211).

IMMUNOGEN INFORMATION

Immunogen

CD14 molecule

Synonyms

CD14, CD14 molecule

Observed MW

50-55 kDa

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P08571

IMAGES

Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab10077(CD14 Antibody) at dilution of 1:200