{"product_id":"new-product-584483","title":"anti- Cdc20 antibody","description":"\u003cp\u003eUnravel the intricate mechanisms governing cell division with our Anti-Cdc20 Antibody, now available in a 100µg size. Cdc20, or cell division cycle 20, is a key regulatory protein essential for the transition from metaphase to anaphase during the cell cycle. It serves as an activator of the anaphase-promoting complex\/cyclosome (APC\/C), orchestrating the degradation of key cell cycle regulators and ensuring accurate chromosome segregation.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eThis monoclonal antibody offers high specificity and sensitivity, making it an indispensable tool for researchers investigating cell cycle regulation, mitosis, and the control of genomic stability. With 100µg of this antibody, you'll have a substantial supply for multiple experiments, ensuring the uninterrupted progression of your research.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eExplore the intricate role of Cdc20 in the cell cycle, its interactions with APC\/C, and its significance in maintaining chromosomal integrity. Investigate the molecular intricacies of Cdc20-mediated processes, contributing to our understanding of cell division control and its implications in cancer and developmental biology.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Name\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCdc20 antibody\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSize\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e100µg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eForm\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eliquid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmunogen affinity purified\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e≥95% as determined by SDS-PAGE\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRabbit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClonality\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003epolyclonal\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIgG\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze \/ thaw cycles.)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBACKGROUND\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eRequired for full ubiquitin ligase activity of the anaphase promoting complex\/cyclosome(APC\/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC\/C ternary complex is inactive and in anaphase the CDC20-APC\/C binary complex is active in degrading substrates. The CDC20-APC\/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC\/C-induced degradation of NEUROD2 induces presynaptic differentiation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIMMUNOGEN INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImmunogen\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ecell division cycle 20 homolog\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCDC20, CDC20A, p55CDC\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e55 kDa\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAPPLICATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTested Application\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eELISA, WB, IHC\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended Dilution\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWB: 1:500-1:2000; IHC: 1:20-1:200\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUNIPROT INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUniProt ID\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"http:\/\/www.uniprot.org\/uniprot\/Q12834\"\u003eQ12834\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIMAGES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e \u003cimg src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image1\/FNab09997.jpg\" data-mce-fragment=\"1\" data-mce-src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image1\/FNab09997.jpg\"\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan data-mce-fragment=\"1\"\u003eImmunohistochemistry of paraffin-embedded human colon cancer using FNab09997(CDC20 antibody) at dilution of 1:10\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/www.fn-test.com\/content\/uploads\/product\/images\/antibody\/image4\/FNab09997.jpg\"\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan data-mce-fragment=\"1\"\u003eHeLa cells were subjected to SDS PAGE followed by western blot with FNab09997(CDC20 antibody) at dilution of 1:1000\u003c\/span\u003e\u003c\/p\u003e","brand":"FineTest","offers":[{"title":"100µg \/ Rabbit \/ polyclonal","offer_id":47549681664280,"sku":"FNab09997","price":260.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/fine_test_logo_3d3d9ce7-d0f4-4675-b108-ebd9b33e7f61.jpg?v=1705721840","url":"https:\/\/danabiosci.com\/products\/new-product-584483","provider":"Dana Bioscience","version":"1.0","type":"link"}