{"product_id":"new-product-581321","title":"VN2R1P Polyclonal Antibody","description":"\u003cp\u003eThe CARL-1 monoclonal antibody reacts with human TWEAK, a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion. TWEAK transcript is expressed broadly in many adult and fetal tissues, however, the staining of human peripheral blood mononuclear cells with monoclonal antibodies shows a more restricted pattern. While freshly isolated PBMCs do not express detectable levels of TWEAK on their surface, IFN-gamma-stimulated blood monocytes rapidly upregulate TWEAK surface expression. TWEAK is expressed as membrane bound and secreted forms. Interaction of TWEAK with its counter-receptor promotes secretion of IL-8, activation of NF-kappaB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. While TWEAK exhibits overlapping signaling functions to TNF, it is generally less effective in inducing apoptosis, giving rise to its name, TNF-like weak inducer of apoptosis. For detection of human TWEAK by sandwich ELISA, a combination of purified CARL-2 for capture and biotinylated CARL-1 for detection is recommended.\u003c\/p\u003e\n\u003cp\u003eThe VN2R1P polyclonal antibody is a highly specific and reliable tool for various research applications. This antibody is produced by immunizing animals with a purified recombinant protein, resulting in a diverse pool of antibodies that recognize different epitopes of the target protein. \u003cbr\u003e\u003cbr\u003eThe VN2R1P polyclonal antibody exhibits exceptional sensitivity and specificity, making it an ideal choice for immunohistochemistry, western blotting, and other protein detection techniques. Its high affinity for the target protein ensures accurate and reproducible results, enabling researchers to confidently analyze protein expression and localization in various biological samples.\u003cbr\u003e\u003cbr\u003eFurthermore, the VN2R1P polyclonal antibody is rigorously tested to ensure batch-to-batch consistency and minimal cross-reactivity with non-target proteins. This guarantees reliable and reproducible data, reducing experimental variability and enhancing the overall quality of research outcomes.\u003cbr\u003e\u003cbr\u003eWith its superior performance and versatility, the VN2R1P polyclonal antibody is an indispensable tool for scientists and researchers in the fields of molecular biology, biochemistry, and immunology. Its exceptional quality and reliability make it an excellent choice for a wide range of applications, facilitating groundbreaking discoveries and advancements in scientific knowledge.\u003cbr\u003e\u003cbr\u003eOrder the VN2R1P polyclonal antibody today and experience the exceptional performance and reliability that it offers.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47548461220120,"sku":"BT-AP15494","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_c081d9fc-4624-4f07-acf1-17f2bc680785.png?v=1705695068","url":"https:\/\/danabiosci.com\/products\/new-product-581321","provider":"Dana Bioscience","version":"1.0","type":"link"}