{"product_id":"new-product-581310","title":"VHL(Phospho Ser68) Polyclonal Antibody","description":"\u003cp\u003eVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e\n\u003cp\u003eThe VHL(PHOSPHO SER68) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of the phosphorylated serine 68 residue on the Von Hippel-Lindau (VHL) protein. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional sensitivity and specificity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe VHL(PHOSPHO SER68) Polyclonal Antibody exhibits outstanding performance in recognizing the phosphorylated serine 68 residue on the VHL protein, enabling researchers to investigate the functional significance of this post-translational modification. With its high affinity and selectivity, this antibody allows for precise and accurate quantification of phosphorylated serine 68 levels in biological samples.\u003cbr\u003e\u003cbr\u003eThis antibody is manufactured under stringent quality control measures, guaranteeing batch-to-batch consistency and reproducibility. It has been extensively validated in various experimental settings, demonstrating its reliability and robustness. The VHL(PHOSPHO SER68) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex antibody preparation procedures.\u003cbr\u003e\u003cbr\u003eWith its exceptional specificity and sensitivity, the VHL(PHOSPHO SER68) Polyclonal Antibody is an indispensable tool for researchers studying the VHL protein and its phosphorylation events. Its versatility and reliability make it an ideal choice for a wide range of applications in both basic and clinical research.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47548459122968,"sku":"BT-AP15470","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_75c5a8b6-9252-4e4e-8ed9-5c70d4f50375.png?v=1705695010","url":"https:\/\/danabiosci.com\/products\/new-product-581310","provider":"Dana Bioscience","version":"1.0","type":"link"}