{"product_id":"new-product-580822","title":"Stat3 Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper\u003c\/p\u003e\n\u003cp\u003eThe STAT3 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of STAT3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human STAT3 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for a wide range of applications in research and diagnostics.\u003cbr\u003e\u003cbr\u003eThe STAT3 Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect both phosphorylated and non-phosphorylated forms of STAT3 protein. The antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.\u003cbr\u003e\u003cbr\u003eThis product is manufactured to the highest quality standards, ensuring consistent performance and reproducibility. It is rigorously tested for purity, specificity, and sensitivity, and is guaranteed to provide reliable and accurate results. The STAT3 Polyclonal Antibody is an essential tool for researchers and clinicians studying the role of STAT3 in various physiological and pathological processes, including cancer, inflammation, and immune response.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47548253110552,"sku":"BT-AP14538","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_92fa5bf4-237c-45a3-a255-65381dbe2cf3.png?v=1705692497","url":"https:\/\/danabiosci.com\/products\/new-product-580822","provider":"Dana Bioscience","version":"1.0","type":"link"}