{"product_id":"new-product-580821","title":"Stat3 (Acetyl-Lys49) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper\u003c\/p\u003e\n\u003cp\u003eThe STAT3 (Acetyl-Lys49) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of STAT3 protein in various biological samples. This antibody is produced using advanced techniques and is purified to ensure maximum specificity and sensitivity.\u003cbr\u003e\u003cbr\u003eSTAT3, also known as signal transducer and activator of transcription 3, is a crucial transcription factor involved in various cellular processes, including cell growth, differentiation, and survival. The acetylation of Lys49 residue in STAT3 has been shown to play a significant role in its activation and subsequent downstream signaling.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody is raised against the acetylated Lys49 residue of STAT3, ensuring its high affinity and specificity towards the acetylated form of the protein. It has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eWith its exceptional sensitivity and specificity, this antibody enables accurate and reliable detection of acetylated STAT3 in a wide range of samples, including cell lysates, tissue extracts, and biological fluids. Its versatility and robustness make it an ideal choice for researchers studying the role of STAT3 acetylation in various physiological and pathological conditions.\u003cbr\u003e\u003cbr\u003eThe STAT3 (Acetyl-Lys49) Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and consistent results. It is provided in a liquid form, allowing for easy handling and minimizing the risk of sample loss or contamination.\u003cbr\u003e\u003cbr\u003eIn summary, the STAT3 (Acetyl-Lys49) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of acetylated STAT3 protein. Its exceptional performance and versatility make it an invaluable asset for researchers in the field of cellular signaling and molecular biology.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47548252651800,"sku":"BT-AP14537","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_4f324040-e2b8-4ebf-8bcb-e41cab1c3e86.png?v=1705692489","url":"https:\/\/danabiosci.com\/products\/new-product-580821","provider":"Dana Bioscience","version":"1.0","type":"link"}