{"product_id":"new-product-580779","title":"SREBP-1 (Acetyl-Lys324) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.\u003c\/p\u003e\n\u003cp\u003eThe SREBP-1 (Acetyl-Lys324) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Sterol Regulatory Element-Binding Protein 1 (SREBP-1) in various biological samples. This antibody is produced using advanced polyclonal antibody technology, ensuring exceptional sensitivity and specificity.\u003cbr\u003e\u003cbr\u003eSREBP-1 is a crucial transcription factor involved in the regulation of lipid metabolism and cholesterol homeostasis. It plays a pivotal role in the synthesis and uptake of cholesterol, fatty acids, and triglycerides. The acetylation of Lysine 324 residue in SREBP-1 has been identified as a critical post-translational modification that modulates its activity and stability.\u003cbr\u003e\u003cbr\u003eThe SREBP-1 (Acetyl-Lys324) Polyclonal Antibody has been meticulously developed and validated to specifically recognize the acetylated form of SREBP-1 at Lysine 324. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results. This antibody is suitable for various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry.\u003cbr\u003e\u003cbr\u003eWith its high affinity and specificity, the SREBP-1 (Acetyl-Lys324) Polyclonal Antibody offers researchers a valuable tool for investigating the role of SREBP-1 in lipid metabolism, cholesterol regulation, and related diseases. Its exceptional performance and reliability make it an indispensable asset for both basic research and clinical studies.\u003cbr\u003e\u003cbr\u003eOrder the SREBP-1 (Acetyl-Lys324) Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing lipid metabolism and cholesterol homeostasis.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47548227649816,"sku":"BT-AP14465","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_8d5f58bc-9b5f-4e1f-9595-889775326afa.png?v=1705692275","url":"https:\/\/danabiosci.com\/products\/new-product-580779","provider":"Dana Bioscience","version":"1.0","type":"link"}