{"product_id":"new-product-580688","title":"Smad2(Phospho Ser250) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation\u003c\/p\u003e\n\u003cp\u003eThe SMAD2(PHOSPHO SER250) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of SMAD2 protein phosphorylated at serine 250. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and sensitivity for the target protein.\u003cbr\u003e\u003cbr\u003eSMAD2 is a critical component of the transforming growth factor-beta (TGF-β) signaling pathway, playing a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Phosphorylation of SMAD2 at serine 250 is known to regulate its activity and downstream signaling events.\u003cbr\u003e\u003cbr\u003eThe SMAD2(PHOSPHO SER250) Polyclonal Antibody has been extensively validated for its specificity and performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated SMAD2 and other related proteins, ensuring accurate and reliable results.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The product is stored at -20°C to maintain its stability and functionality.\u003cbr\u003e\u003cbr\u003eResearchers and scientists in the fields of cell biology, molecular biology, and signal transduction will greatly benefit from the SMAD2(PHOSPHO SER250) Polyclonal Antibody, as it enables precise and efficient detection of phosphorylated SMAD2, facilitating a deeper understanding of TGF-β signaling and its implications in various biological processes.\u003cbr\u003e\u003cbr\u003eOrder your SMAD2(PHOSPHO SER250) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of cellular signaling pathways.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47548174958872,"sku":"BT-AP14290","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_530f9caa-2afb-4a04-8382-0862fa040131.png?v=1705691820","url":"https:\/\/danabiosci.com\/products\/new-product-580688","provider":"Dana Bioscience","version":"1.0","type":"link"}