{"product_id":"new-product-580652","title":"SIGIR Polyclonal Antibody","description":"\u003cp\u003eActs as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.,Belongs to the interleukin-1 receptor family.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 TIR domain.,subunit:Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6.,tissue specificity:Mainly expressed in epithelial tissues such as kidney, lung and gut.,\u003c\/p\u003e\n\u003cp\u003eIntroducing the SIGIR Polyclonal Antibody, a cutting-edge immunological tool designed to facilitate advanced research in the field of signal transduction. This meticulously crafted antibody is meticulously developed using state-of-the-art techniques, ensuring exceptional specificity and sensitivity for accurate detection and analysis of SIGIR protein expression.\u003cbr\u003e\u003cbr\u003eThe SIGIR Polyclonal Antibody boasts a high affinity for SIGIR, a crucial protein involved in signal transduction pathways. Its exceptional specificity enables researchers to confidently investigate the intricate mechanisms underlying cellular signaling processes. With this antibody, scientists can delve deeper into the intricate interplay between SIGIR and its associated molecules, unraveling novel insights into cellular communication.\u003cbr\u003e\u003cbr\u003eThis antibody's remarkable sensitivity allows for precise detection of even low levels of SIGIR expression, enabling researchers to explore its role in various physiological and pathological conditions. Its unparalleled performance ensures reliable and reproducible results, empowering scientists to make significant strides in understanding the complex signaling networks that govern cellular behavior.\u003cbr\u003e\u003cbr\u003eThe SIGIR Polyclonal Antibody is meticulously manufactured using cutting-edge techniques, guaranteeing batch-to-batch consistency and reliability. Rigorous quality control measures are implemented throughout the production process to ensure optimal performance and reliability. Each vial of this antibody is accompanied by a comprehensive datasheet, providing detailed information on its recommended applications, storage conditions, and handling instructions.\u003cbr\u003e\u003cbr\u003eIn summary, the SIGIR Polyclonal Antibody represents a breakthrough tool for researchers seeking to unravel the intricate mechanisms of signal transduction. With its exceptional specificity, sensitivity, and reliability, this antibody empowers scientists to explore the role of SIGIR in various cellular processes, paving the way for groundbreaking discoveries in the field of cellular signaling.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47548146319640,"sku":"BT-AP14223","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_98d96944-e50c-4994-87db-6a4d81551ea4.png?v=1705691633","url":"https:\/\/danabiosci.com\/products\/new-product-580652","provider":"Dana Bioscience","version":"1.0","type":"link"}