{"product_id":"new-product-580252","title":"Rad17(Phospho Ser646) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h\u003c\/p\u003e\n\u003cp\u003eThe RAD17(PHOSPHO SER646) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of RAD17 protein phosphorylated at serine 646. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eRAD17 is a crucial component of the DNA damage response pathway, playing a vital role in maintaining genomic stability. Phosphorylation of RAD17 at serine 646 has been implicated in the regulation of its function and activation during DNA damage repair processes. Therefore, the RAD17(PHOSPHO SER646) Polyclonal Antibody serves as an invaluable tool for researchers studying DNA damage response mechanisms and related cellular processes.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of RAD17 phosphorylated at serine 646 in various sample types.\u003cbr\u003e\u003cbr\u003eThe RAD17(PHOSPHO SER646) Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming antibody preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance and reliability, the RAD17(PHOSPHO SER646) Polyclonal Antibody is an indispensable tool for researchers in the field of DNA damage response and related studies. Its high specificity and sensitivity make it an ideal choice for accurate and precise detection of RAD17 phosphorylated at serine 646, facilitating a deeper understanding of cellular processes involved in DNA damage repair.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547910390040,"sku":"BT-AP13501","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_331568f2-dfdb-4bc7-9da6-a6b0ba94dde8.png?v=1705689533","url":"https:\/\/danabiosci.com\/products\/new-product-580252","provider":"Dana Bioscience","version":"1.0","type":"link"}