{"product_id":"new-product-580185","title":"PTEN(Phospho Ser380\/T382\/T383) Polyclonal Antibody","description":"\u003cp\u003eThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener\u003c\/p\u003e\n\u003cp\u003eIntroducing the PTEN Phospho-Ser380\/T382\/T383 Polyclonal Antibody, meticulously developed by BT Lab, a renowned name in the field of life sciences. This cutting-edge antibody is designed to detect and analyze the phosphorylation of PTEN at serine residues 380, 382, and 383, enabling researchers to gain valuable insights into the intricate regulatory mechanisms of this critical protein.\u003cbr\u003e\u003cbr\u003eCrafted with utmost precision and utilizing state-of-the-art technology, this polyclonal antibody exhibits exceptional specificity and sensitivity, ensuring accurate and reliable results. Its high affinity towards the phosphorylated form of PTEN guarantees optimal performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe PTEN Phospho-Ser380\/T382\/T383 Polyclonal Antibody offers researchers an invaluable tool to investigate the dynamic phosphorylation events occurring at these specific serine residues. By elucidating the functional consequences of PTEN phosphorylation, this antibody opens up new avenues for understanding the intricate signaling pathways involved in cellular processes such as cell growth, proliferation, and survival.\u003cbr\u003e\u003cbr\u003eWith its robust performance and versatility, this antibody is an indispensable asset for scientists engaged in cancer research, molecular biology, and signal transduction studies. Its reliable and reproducible results empower researchers to unravel the complexities of PTEN regulation, paving the way for potential therapeutic interventions and targeted treatments.\u003cbr\u003e\u003cbr\u003eChoose the PTEN Phospho-Ser380\/T382\/T383 Polyclonal Antibody from BT Lab to unlock the full potential of your research. Trust in our commitment to excellence and join the ranks of countless scientists who rely on our cutting-edge products to advance scientific knowledge and make groundbreaking discoveries.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547853013272,"sku":"BT-AP13370","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_62085296-d34c-45c8-ba7a-ef386654fd0c.png?v=1705689153","url":"https:\/\/danabiosci.com\/products\/new-product-580185","provider":"Dana Bioscience","version":"1.0","type":"link"}