{"product_id":"new-product-580184","title":"PTEN(Phospho Ser380) Polyclonal Antibody","description":"\u003cp\u003eThis gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener\u003c\/p\u003e\n\u003cp\u003eIntroducing the PTEN Phospho-Ser380 Polyclonal Antibody, meticulously developed by BT Lab, a renowned name in the field of life sciences. This cutting-edge antibody is designed to specifically target and detect the phosphorylated form of PTEN at serine 380 residue, enabling researchers to delve deeper into the intricate mechanisms of cellular signaling pathways.\u003cbr\u003e\u003cbr\u003eCrafted with utmost precision and utilizing state-of-the-art technology, this antibody exhibits exceptional sensitivity and specificity, ensuring accurate and reliable results. Its high affinity towards the phosphorylated PTEN at serine 380 residue allows for precise identification and quantification, facilitating comprehensive analysis of PTEN-mediated cellular processes.\u003cbr\u003e\u003cbr\u003eThe PTEN Phospho-Ser380 Polyclonal Antibody is meticulously validated through rigorous quality control measures, guaranteeing optimal performance and reproducibility. Its exceptional performance is further enhanced by its compatibility with various applications, including Western blotting, immunohistochemistry, and immunofluorescence, providing researchers with versatile options to explore PTEN phosphorylation dynamics across diverse experimental setups.\u003cbr\u003e\u003cbr\u003eWith its user-friendly protocol and straightforward application, this antibody offers convenience and efficiency, streamlining experimental workflows and saving valuable time. Its robust formulation ensures long-term stability, allowing for extended usage without compromising performance, making it an ideal choice for long-term research projects.\u003cbr\u003e\u003cbr\u003eIn summary, the PTEN Phospho-Ser380 Polyclonal Antibody by BT Lab is a highly reliable and efficient tool for investigating PTEN phosphorylation events. Backed by BT Lab's commitment to excellence, this antibody empowers researchers to unravel the complexities of PTEN-mediated cellular signaling, paving the way for groundbreaking discoveries in the field of life sciences.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547852882200,"sku":"BT-AP13369","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_05b60f24-0857-40cb-8571-a00c8ecf7839.png?v=1705689150","url":"https:\/\/danabiosci.com\/products\/new-product-580184","provider":"Dana Bioscience","version":"1.0","type":"link"}