{"product_id":"new-product-580072","title":"PLB(Phospho Ser16\/T17) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.\u003c\/p\u003e\n\u003cp\u003eThe PLB Phospho-Ser16\/T17 Polyclonal Antibody, manufactured by BT Lab and distributed by Dana Biosciences, is a highly specific and sensitive tool for the detection of phospholamban (PLB) phosphorylation at serine residues 16 and 17. This antibody is produced using high-quality polyclonal antibodies that have been rigorously tested for specificity and sensitivity, ensuring reliable and reproducible results.\u003cbr\u003e\u003cbr\u003eThe PLB Phospho-Ser16\/T17 Polyclonal Antibody is suitable for use in a variety of applications, including western blotting, immunoprecipitation, and immunohistochemistry. It has been validated for use in human, mouse, and rat samples, making it a versatile tool for researchers in a range of fields.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied in a convenient 100 µg size, and is provided as a lyophilized powder for ease of storage and handling. It is recommended for use at a dilution of 1:1000 for western blotting, and 1:200 for immunohistochemistry.\u003cbr\u003e\u003cbr\u003eOverall, the PLB Phospho-Ser16\/T17 Polyclonal Antibody is a reliable and effective tool for the detection of PLB phosphorylation, and is an essential component of any researcher's toolkit.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547728101656,"sku":"BT-AP13150","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5039386f-a314-45a6-926d-588cdab78559.png?v=1705688559","url":"https:\/\/danabiosci.com\/products\/new-product-580072","provider":"Dana Bioscience","version":"1.0","type":"link"}