{"product_id":"new-product-579972","title":"PDK3 Polyclonal Antibody","description":"\u003cp\u003eThe pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation\/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe PDK3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of pyruvate dehydrogenase kinase 3 (PDK3) protein in various biological samples. This antibody is produced using state-of-the-art techniques, ensuring high affinity and specificity towards PDK3.\u003cbr\u003e\u003cbr\u003ePDK3 is a key regulatory enzyme involved in the inhibition of pyruvate dehydrogenase complex (PDC), which plays a crucial role in the regulation of glucose metabolism. Dysregulation of PDK3 has been implicated in various diseases, including cancer, diabetes, and cardiovascular disorders. Therefore, accurate measurement of PDK3 protein levels is essential for understanding its role in disease pathogenesis and for the development of targeted therapies.\u003cbr\u003e\u003cbr\u003eThe PDK3 Polyclonal Antibody exhibits excellent performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in multiple species, including human, mouse, and rat, ensuring its versatility and applicability in diverse research settings.\u003cbr\u003e\u003cbr\u003eWith its high sensitivity and specificity, the PDK3 Polyclonal Antibody offers researchers a reliable tool for studying the expression and regulation of PDK3 protein. Its superior performance and broad applicability make it an indispensable asset for researchers in the fields of metabolism, cancer biology, and drug discovery.\u003cbr\u003e\u003cbr\u003eOrder the PDK3 Polyclonal Antibody today and unlock new insights into the role of PDK3 in disease pathogenesis and therapeutic interventions.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547654111512,"sku":"BT-AP12905","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_a5c6132f-dbf1-442b-a9d7-a6aab7085f98.png?v=1705688079","url":"https:\/\/danabiosci.com\/products\/new-product-579972","provider":"Dana Bioscience","version":"1.0","type":"link"}