{"product_id":"new-product-579945","title":"PD-L2 Polyclonal Antibody","description":"\u003cp\u003eInvolved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.,induction:Up-regulated by IFNG stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4.,Belongs to the immunoglobulin superfamily. BTN\/MOG family.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PDCD1.,tissue specificity:Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.,\u003c\/p\u003e\n\u003cp\u003eThe PD-L2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of programmed death-ligand 2 (PD-L2) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PD-L2 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity through various assays.\u003cbr\u003e\u003cbr\u003eThe PD-L2 protein is a member of the B7 family of co-stimulatory molecules that plays a crucial role in regulating the immune response. It is expressed on the surface of antigen-presenting cells and interacts with its receptor, programmed death-1 (PD-1), on T cells to inhibit T cell activation and proliferation. Dysregulation of the PD-L2\/PD-1 pathway has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases.\u003cbr\u003e\u003cbr\u003eThe PD-L2 Polyclonal Antibody is an essential tool for researchers studying the PD-L2\/PD-1 pathway and its role in disease pathogenesis. It can be used for various applications, including Western blotting, immunohistochemistry, and flow cytometry. This antibody has been validated for its specificity and sensitivity in detecting PD-L2 protein in human, mouse, and rat samples.\u003cbr\u003e\u003cbr\u003eIn summary, the PD-L2 Polyclonal Antibody is a reliable and high-quality antibody that can be used for the detection of PD-L2 protein in various biological samples. Its specificity and sensitivity make it an essential tool for researchers studying the PD-L2\/PD-1 pathway and its role in disease pathogenesis.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547624522008,"sku":"BT-AP12855","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_acef59f7-325f-4e08-a8c3-8250bc319c76.png?v=1705687919","url":"https:\/\/danabiosci.com\/products\/new-product-579945","provider":"Dana Bioscience","version":"1.0","type":"link"}