{"product_id":"new-product-579842","title":"p53(Phospho Ser6) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).\u003c\/p\u003e\n\u003cp\u003eThe p53(Phospho Ser6) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 6 residue on the p53 protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eThe p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of serine 6 on p53 has been implicated in various cellular processes, including transcriptional activation and stabilization of the protein. Therefore, the ability to accurately measure the phosphorylation status of serine 6 on p53 is of great importance in understanding its functional significance.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody exhibits exceptional specificity towards phosphorylated serine 6 on p53, with minimal cross-reactivity to other phosphorylated residues or non-phosphorylated forms of p53. It has been extensively validated using various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring its suitability for a wide range of applications.\u003cbr\u003e\u003cbr\u003eThe p53(Phospho Ser6) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without compromising its quality. The antibody is also accompanied by comprehensive technical documentation, including recommended protocols and storage conditions, to facilitate successful implementation in the laboratory.\u003cbr\u003e\u003cbr\u003eIn summary, the p53(Phospho Ser6) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of phosphorylated serine 6 on the p53 protein. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers studying the intricate mechanisms underlying p53-mediated cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547411497240,"sku":"BT-AP12674","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_1fb92234-abfd-4eca-b898-3558278729e8.png?v=1705687360","url":"https:\/\/danabiosci.com\/products\/new-product-579842","provider":"Dana Bioscience","version":"1.0","type":"link"}