{"product_id":"new-product-579838","title":"p53(Phospho Ser315) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).\u003c\/p\u003e\n\u003cp\u003eThe p53(Phospho Ser315) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 315 residue on the p53 protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eThe p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of serine 315 on p53 has been implicated in various cellular processes, including the activation of p53-mediated transcriptional activity and the induction of cell cycle arrest. Therefore, the detection and analysis of phosphorylated serine 315 on p53 are of great importance in understanding the molecular mechanisms underlying these cellular processes.\u003cbr\u003e\u003cbr\u003eThe p53(Phospho Ser315) Polyclonal Antibody exhibits high specificity towards phosphorylated serine 315 on p53, with minimal cross-reactivity to other phosphorylated residues or non-phosphorylated forms of p53. This antibody has been extensively validated using various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring its suitability for a wide range of applications.\u003cbr\u003e\u003cbr\u003eWith its superior sensitivity and specificity, the p53(Phospho Ser315) Polyclonal Antibody enables accurate and reliable detection and quantification of phosphorylated serine 315 on p53 in various biological samples. Its robust performance and consistent results make it an invaluable tool for researchers and scientists studying the role of p53 in cellular processes and its potential implications in disease development and progression.\u003cbr\u003e\u003cbr\u003eOrder the p53(Phospho Ser315) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of p53-mediated cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547396489496,"sku":"BT-AP12670","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_c40e746f-2860-4064-82e3-0ae9eb55104b.png?v=1705687343","url":"https:\/\/danabiosci.com\/products\/new-product-579838","provider":"Dana Bioscience","version":"1.0","type":"link"}