{"product_id":"new-product-579816","title":"p300 (Acetyl Lys1542) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.\u003c\/p\u003e\n\u003cp\u003eThe p300 (Acetyl Lys1542) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p300 protein in various biological samples. This antibody has been extensively validated and characterized to ensure its reliability and accuracy in experimental settings.\u003cbr\u003e\u003cbr\u003eThe p300 protein plays a crucial role in the regulation of gene expression and is involved in a wide range of cellular processes, including cell proliferation, differentiation, and apoptosis. The acetylation of lysine residue 1542 on p300 has been shown to be important for its enzymatic activity and transcriptional co-activator function.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been raised against a synthetic peptide corresponding to the acetylated lysine 1542 region of the p300 protein. It has been purified using affinity chromatography and is supplied as a ready-to-use solution for convenience and ease of use.\u003cbr\u003e\u003cbr\u003eThe p300 (Acetyl Lys1542) Polyclonal Antibody exhibits high specificity and sensitivity, allowing for accurate detection and quantification of p300 protein levels in various sample types, including cell lysates, tissue extracts, and biological fluids. It is suitable for use in a variety of applications, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eWith its reliable performance and excellent quality, the p300 (Acetyl Lys1542) Polyclonal Antibody is an essential tool for researchers studying the role of p300 protein in cellular processes and its potential implications in various diseases.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547360477464,"sku":"BT-AP12630","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_fb17464a-725a-49aa-9ea1-74a8027dd99f.png?v=1705687239","url":"https:\/\/danabiosci.com\/products\/new-product-579816","provider":"Dana Bioscience","version":"1.0","type":"link"}