{"product_id":"new-product-579455","title":"NLK Polyclonal Antibody","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin.,Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt\/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7\/TAK1 to phosphorylate STAT3.,PTM:Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme.,Belongs to the protein kinase superfamily. CMGC Ser\/Thr protein kinase family. MAP kinase subfamily.,Contains 1 protein kinase domain.,subcellular location:Predominantly nuclear. A smaller fraction is cytoplasmic.,subunit:Interacts with STAT3 (By similarity). Interacts with RNF138\/NARF and TCF7L2\/TCF4. Interacts with HIPK2 and MYB.,\u003c\/p\u003e\n\u003cp\u003eThe NLK Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of NLK protein expression in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, ensuring accurate and reproducible results.\u003cbr\u003e\u003cbr\u003eThe NLK Polyclonal Antibody is produced using state-of-the-art techniques, guaranteeing high purity and batch-to-batch consistency. It has been rigorously tested for cross-reactivity with other proteins to ensure its specificity for NLK. This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eWith its superior performance, the NLK Polyclonal Antibody enables researchers to investigate the role of NLK in various cellular processes and pathways. It provides valuable insights into the molecular mechanisms underlying development, differentiation, and disease progression.\u003cbr\u003e\u003cbr\u003eThe NLK Polyclonal Antibody is available in various sizes to meet the specific needs of different experiments. It is supplied in a convenient and ready-to-use format, allowing for easy and efficient handling. Each batch is accompanied by a detailed datasheet, providing comprehensive information on the antibody's characteristics and recommended protocols.\u003cbr\u003e\u003cbr\u003eChoose the NLK Polyclonal Antibody for your research needs and unlock the potential of NLK protein analysis. Experience reliable and accurate results with this high-quality antibody, designed to advance your scientific discoveries.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47547026080024,"sku":"BT-AP11908","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_7796b36c-08f7-4396-b083-c5738ef9e8a6.png?v=1705685406","url":"https:\/\/danabiosci.com\/products\/new-product-579455","provider":"Dana Bioscience","version":"1.0","type":"link"}