{"product_id":"new-product-579291","title":"MSK1(Phospho Ser360) Polyclonal Antibody","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Appears to be activated by multiple phosphorylations on threonine and serine residues. ERK1\/2 and MAPK14\/p38-alpha may play a role in this process.,Serine\/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos\/FOS and c-jun\/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).,miscellaneous:Enzyme activity requires the presence of both kinase domains.,PTM:Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the Catalytic activity of the N-terminal kinase domain.,Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. S6 kinase subfamily.,Contains 1 AGC-kinase C-terminal domain.,Contains 2 protein kinase domains.,subcellular location:Predominantly nuclear. Partially cytoplasmic.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14\/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.,tissue specificity:Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.,\u003c\/p\u003e\n\u003cp\u003eThe MSK1(Phospho Ser360) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of MSK1 protein phosphorylated at Ser360. This antibody has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe MSK1 protein plays a crucial role in cellular signaling pathways, particularly in the regulation of gene expression. Phosphorylation of MSK1 at Ser360 is known to be involved in the activation of downstream targets, leading to the modulation of various cellular processes.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been developed using state-of-the-art techniques and high-quality materials to ensure optimal performance and reliability. It exhibits excellent specificity, showing minimal cross-reactivity with non-phosphorylated MSK1 or other related proteins.\u003cbr\u003e\u003cbr\u003eWith its high sensitivity, this antibody allows for the detection of low levels of phosphorylated MSK1, enabling accurate and precise quantification. Its versatility in different applications makes it a valuable tool for researchers studying MSK1 signaling pathways and its role in various physiological and pathological conditions.\u003cbr\u003e\u003cbr\u003eThe MSK1(Phospho Ser360) Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is provided in a liquid form, allowing for easy handling and storage.\u003cbr\u003e\u003cbr\u003eIn summary, the MSK1(Phospho Ser360) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of phosphorylated MSK1 protein. Its high specificity, sensitivity, and versatility make it an essential reagent for researchers in the field of cellular signaling and gene expression regulation.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546954383640,"sku":"BT-AP11544","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_9ad05bf8-bf4b-4c16-8129-7d981226bff0.png?v=1705684551","url":"https:\/\/danabiosci.com\/products\/new-product-579291","provider":"Dana Bioscience","version":"1.0","type":"link"}