{"product_id":"new-product-579290","title":"MSK1(Phospho Ser212) Polyclonal Antibody","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Appears to be activated by multiple phosphorylations on threonine and serine residues. ERK1\/2 and MAPK14\/p38-alpha may play a role in this process.,Serine\/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos\/FOS and c-jun\/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).,miscellaneous:Enzyme activity requires the presence of both kinase domains.,PTM:Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the Catalytic activity of the N-terminal kinase domain.,Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. S6 kinase subfamily.,Contains 1 AGC-kinase C-terminal domain.,Contains 2 protein kinase domains.,subcellular location:Predominantly nuclear. Partially cytoplasmic.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14\/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.,tissue specificity:Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.,\u003c\/p\u003e\n\u003cp\u003eThe MSK1(Phospho Ser212) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MSK1 protein phosphorylated at Serine 212. This antibody is produced using state-of-the-art techniques and exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe MSK1 protein plays a crucial role in cellular signaling pathways, particularly in the regulation of gene expression and cell proliferation. Phosphorylation of MSK1 at Serine 212 is known to be a key event in its activation and subsequent downstream signaling cascades. Therefore, the ability to accurately detect and measure this phosphorylation event is of utmost importance in understanding the functional implications of MSK1 in various biological processes.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody has been rigorously validated for its specificity and sensitivity, ensuring reliable and reproducible results. It exhibits minimal cross-reactivity with non-phosphorylated MSK1 and other related proteins, thereby enabling precise detection of the phosphorylated form of MSK1.\u003cbr\u003e\u003cbr\u003eThe MSK1(Phospho Ser212) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, allowing for easy storage and handling.\u003cbr\u003e\u003cbr\u003eIn summary, the MSK1(Phospho Ser212) Polyclonal Antibody is an indispensable tool for researchers studying MSK1 signaling pathways and its role in various biological processes. Its exceptional specificity, sensitivity, and ease of use make it an ideal choice for accurate detection and quantification of phosphorylated MSK1 at Serine 212.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546953498904,"sku":"BT-AP11543","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_9ad54e0d-06e9-43e2-bd30-6fb8f97b4da8.png?v=1705684538","url":"https:\/\/danabiosci.com\/products\/new-product-579290","provider":"Dana Bioscience","version":"1.0","type":"link"}