{"product_id":"new-product-579238","title":"MLK1\/2(Phospho Thr312\/266) Polyclonal Antibody","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,Belongs to the protein kinase superfamily. STE Ser\/Thr protein kinase family. MAP kinase kinase kinase subfamily.,Contains 1 protein kinase domain.,Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,\u003c\/p\u003e\n\u003cp\u003eThe MLK1\/2(Phospho Thr312\/266) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MLK1\/2 protein phosphorylated at Thr312\/266 residues. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eThe MLK1\/2 protein, also known as mixed lineage kinase 1\/2, plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Phosphorylation of MLK1\/2 at Thr312\/266 residues is a key regulatory event that modulates its activity and downstream signaling pathways.\u003cbr\u003e\u003cbr\u003eThis polyclonal antibody is raised in rabbits using a synthetic peptide corresponding to the phosphorylated Thr312\/266 region of MLK1\/2 protein. It exhibits high affinity and specificity towards the phosphorylated form of MLK1\/2, enabling accurate detection and quantification in various experimental settings.\u003cbr\u003e\u003cbr\u003eThe MLK1\/2(Phospho Thr312\/266) Polyclonal Antibody has been extensively validated for its performance in Western blotting, immunohistochemistry, and immunofluorescence applications. It demonstrates excellent sensitivity and minimal cross-reactivity with non-phosphorylated MLK1\/2 protein, ensuring reliable and specific results.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation in a convenient size of 100 µg, allowing for multiple experiments. It is recommended to store the antibody at -20°C for long-term stability. Prior to use, it is advised to aliquot the antibody to avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003cbr\u003eIn summary, the MLK1\/2(Phospho Thr312\/266) Polyclonal Antibody is a valuable tool for researchers studying the phosphorylation status and functional implications of MLK1\/2 protein. Its high specificity, sensitivity, and reliable performance make it an essential component of any study involving MLK1\/2 signaling pathways.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546915094808,"sku":"BT-AP11373","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_edb6b2d9-27da-4f17-a727-9c3112a05de0.png?v=1705684288","url":"https:\/\/danabiosci.com\/products\/new-product-579238","provider":"Dana Bioscience","version":"1.0","type":"link"}