{"product_id":"new-product-579187","title":"MEK-3(Phospho Thr222) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14\/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.\u003c\/p\u003e\n\u003cp\u003eThe MEK-3(Phospho Thr222) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MEK-3 protein phosphorylated at threonine 222. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eThe MEK-3 protein, also known as MAP2K3, plays a crucial role in the mitogen-activated protein kinase (MAPK) signaling pathway. Phosphorylation of MEK-3 at threonine 222 is a key regulatory event that modulates its activity and downstream signaling cascades. Therefore, the ability to accurately measure the phosphorylation status of MEK-3 at this specific site is of great importance in understanding the intricate mechanisms of cellular signaling.\u003cbr\u003e\u003cbr\u003eThe MEK-3(Phospho Thr222) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling reliable detection and quantification of phosphorylated MEK-3 in various biological samples. It has been extensively validated for use in Western blotting, immunoprecipitation, immunofluorescence, and other relevant applications.\u003cbr\u003e\u003cbr\u003eThis antibody is produced using high-quality materials and rigorous quality control measures to ensure consistent performance and reproducibility. It is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage.\u003cbr\u003e\u003cbr\u003eIn summary, the MEK-3(Phospho Thr222) Polyclonal Antibody is a valuable tool for researchers studying the MAPK signaling pathway and its associated cellular processes. Its high specificity, sensitivity, and reliability make it an ideal choice for accurate detection and quantification of phosphorylated MEK-3 protein.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546872004888,"sku":"BT-AP11256","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5cc6e8f6-bf8c-4ccb-ab77-7289a8e8cee2.png?v=1705684033","url":"https:\/\/danabiosci.com\/products\/new-product-579187","provider":"Dana Bioscience","version":"1.0","type":"link"}