{"product_id":"new-product-579186","title":"MEK-3(Phospho Ser218) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14\/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.\u003c\/p\u003e\n\u003cp\u003eThe MEK-3(Phospho Ser218) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MEK-3 protein phosphorylated at Ser218. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eMEK-3, also known as MAP2K3, is a crucial component of the mitogen-activated protein kinase (MAPK) signaling pathway. It plays a pivotal role in cellular processes such as cell proliferation, differentiation, and survival. Phosphorylation of MEK-3 at Ser218 is a key regulatory event that modulates its activity and downstream signaling cascades.\u003cbr\u003e\u003cbr\u003eThe MEK-3(Phospho Ser218) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated MEK-3 in complex biological samples.\u003cbr\u003e\u003cbr\u003eThis antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effective and efficient experiments. The MEK-3(Phospho Ser218) Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.\u003cbr\u003e\u003cbr\u003eIn summary, the MEK-3(Phospho Ser218) Polyclonal Antibody is a valuable research tool for investigating the role of MEK-3 phosphorylation in cellular signaling pathways. Its high specificity, sensitivity, and versatility make it an ideal choice for scientists and researchers working in the fields of cell biology, molecular biology, and signal transduction.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546871775512,"sku":"BT-AP11255","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_348cca71-4827-4ea5-95e4-40b1f4848be7.png?v=1705684029","url":"https:\/\/danabiosci.com\/products\/new-product-579186","provider":"Dana Bioscience","version":"1.0","type":"link"}