{"product_id":"new-product-579164","title":"MED28 Polyclonal Antibody","description":"\u003cp\u003eComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2\/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.,induction:Up-regulated by endothelial cells when exposed to tumor conditional media.,Belongs to the Mediator complex subunit 28 family.,subcellular location:According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.,subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6\/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Forms a ternary complex with NF2\/merlin and GRB2. Binds to actin.,tissue specificity:Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.,\u003c\/p\u003e\n\u003cp\u003eThe MED28 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of MED28 protein expression in various biological samples. This antibody has been extensively validated for its exceptional sensitivity and specificity, ensuring accurate and reproducible results.\u003cbr\u003e\u003cbr\u003eThe MED28 Polyclonal Antibody is produced using state-of-the-art techniques, guaranteeing high purity and batch-to-batch consistency. It has been rigorously tested in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence, demonstrating its versatility and reliability.\u003cbr\u003e\u003cbr\u003eWith its excellent performance characteristics, the MED28 Polyclonal Antibody is an ideal choice for researchers and scientists working in the fields of molecular biology, biochemistry, and cell biology. It enables the investigation of MED28 protein expression and its role in various cellular processes, such as transcriptional regulation and RNA polymerase II-mediated transcription.\u003cbr\u003e\u003cbr\u003eThe MED28 Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy and efficient experimentation. It is provided in a liquid form, ensuring quick and hassle-free handling. Additionally, it is available in different sizes to accommodate various experimental needs.\u003cbr\u003e\u003cbr\u003eChoose the MED28 Polyclonal Antibody for its exceptional quality, reliability, and performance. It is a valuable tool for advancing scientific research and understanding the intricate mechanisms underlying cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546857718040,"sku":"BT-AP11216","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5c39a614-94c6-4645-ae4e-496c87240c5c.png?v=1705683916","url":"https:\/\/danabiosci.com\/products\/new-product-579164","provider":"Dana Bioscience","version":"1.0","type":"link"}