{"product_id":"new-product-579151","title":"MDC1(Phospho Ser513) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2\/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.\u003c\/p\u003e\n\u003cp\u003eThe MDC1(Phospho Ser513) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of MDC1 protein phosphorylated at Ser513. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.\u003cbr\u003e\u003cbr\u003eMDC1, also known as mediator of DNA damage checkpoint protein 1, plays a crucial role in the DNA damage response pathway. Phosphorylation of MDC1 at Ser513 has been implicated in the regulation of DNA repair and cell cycle progression. Therefore, the MDC1(Phospho Ser513) Polyclonal Antibody serves as an invaluable tool for researchers studying these processes.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent performance in detecting endogenous levels of phosphorylated MDC1 in various cell and tissue types.\u003cbr\u003e\u003cbr\u003eThe MDC1(Phospho Ser513) Polyclonal Antibody is supplied as a liquid formulation, allowing for easy handling and storage. It is provided in a convenient size, ensuring cost-effectiveness and minimizing waste.\u003cbr\u003e\u003cbr\u003eIn summary, the MDC1(Phospho Ser513) Polyclonal Antibody is a reliable and efficient tool for investigating the phosphorylation status of MDC1 at Ser513. Its high specificity, sensitivity, and versatility make it an essential component of any research project focused on understanding the DNA damage response pathway and its implications in various biological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546850443544,"sku":"BT-AP11194","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_99376558-b03f-4523-9298-0bfb379857f5.png?v=1705683842","url":"https:\/\/danabiosci.com\/products\/new-product-579151","provider":"Dana Bioscience","version":"1.0","type":"link"}