{"product_id":"new-product-578967","title":"LATS1\/2(Phospho Thr1079\/1041) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is a putative serine\/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2\/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen\u003c\/p\u003e\n\u003cp\u003eThe LATS1\/2(Phospho Thr1079\/1041) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of LATS1 and LATS2 proteins phosphorylated at Thr1079 and Thr1041 residues, respectively. This antibody is produced using advanced techniques to ensure high affinity and specificity, making it an ideal choice for various applications in research and diagnostics.\u003cbr\u003e\u003cbr\u003eThe LATS1\/2(Phospho Thr1079\/1041) Polyclonal Antibody exhibits exceptional performance in immunoblotting, immunoprecipitation, and immunofluorescence assays. It recognizes the phosphorylated forms of LATS1 and LATS2 proteins with remarkable sensitivity, enabling accurate quantification and analysis of these critical signaling molecules.\u003cbr\u003e\u003cbr\u003eThis antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It has been extensively validated in various experimental settings, demonstrating its reliability and robustness. The LATS1\/2(Phospho Thr1079\/1041) Polyclonal Antibody is suitable for use in diverse research areas, including cancer biology, cell signaling, and developmental biology.\u003cbr\u003e\u003cbr\u003eWith its exceptional specificity and sensitivity, the LATS1\/2(Phospho Thr1079\/1041) Polyclonal Antibody offers researchers a valuable tool for investigating the role of LATS1 and LATS2 proteins in cellular processes and disease mechanisms. Its high-quality performance and reliability make it an indispensable asset for scientists seeking to unravel the complexities of protein phosphorylation and its impact on cellular signaling pathways.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546670743832,"sku":"BT-AP10852","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_e90eb211-8da3-4ae9-95dc-aaec6d237f78.png?v=1705682553","url":"https:\/\/danabiosci.com\/products\/new-product-578967","provider":"Dana Bioscience","version":"1.0","type":"link"}