{"product_id":"new-product-578934","title":"Ksr-1(Phospho Ser392) Polyclonal Antibody","description":"\u003cp\u003eThe sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.,PTM:Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated.,Belongs to the protein kinase superfamily. TKL Ser\/Thr protein kinase family.,Contains 1 phorbol-ester\/DAG-type zinc finger.,Contains 1 protein kinase domain.,subcellular location:In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.,subunit:Interacts with HSPCA\/HSP90, YWHAB\/14-3-3, CDC37, MAP2K\/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK\/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization.,\u003c\/p\u003e\n\u003cp\u003eThe Ksr-1(Phospho Ser392) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Ksr-1 protein phosphorylated at Ser392. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target epitope.\u003cbr\u003e\u003cbr\u003eThe Ksr-1 protein plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. Phosphorylation of Ksr-1 at Ser392 has been implicated in the regulation of its activity and downstream signaling pathways. Therefore, the Ksr-1(Phospho Ser392) Polyclonal Antibody serves as an invaluable tool for studying the functional significance of Ksr-1 phosphorylation in cellular processes and disease states.\u003cbr\u003e\u003cbr\u003eThis antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated Ksr-1 protein in complex biological samples.\u003cbr\u003e\u003cbr\u003eThe Ksr-1(Phospho Ser392) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effective and efficient experimentation. The antibody is manufactured under strict quality control measures, guaranteeing consistent and reproducible results.\u003cbr\u003e\u003cbr\u003eIn summary, the Ksr-1(Phospho Ser392) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of phosphorylated Ksr-1 protein. Its exceptional performance and versatility make it an ideal choice for researchers studying the role of Ksr-1 phosphorylation in cellular processes and disease mechanisms.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546650263832,"sku":"BT-AP10762","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_96cd49f6-abeb-4873-9e1e-e4bf06ab776b.png?v=1705682364","url":"https:\/\/danabiosci.com\/products\/new-product-578934","provider":"Dana Bioscience","version":"1.0","type":"link"}