{"product_id":"new-product-578546","title":"Histone H3(Phospho Thr118) Polyclonal Antibody","description":"\u003cp\u003eHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.\u003c\/p\u003e\n\u003cp\u003eThe Histone H3(Phospho Thr118) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated Histone H3 at Thr118 residue. This antibody is produced using advanced immunization techniques and exhibits exceptional affinity and selectivity towards the phosphorylated form of Histone H3 at Thr118. \u003cbr\u003e\u003cbr\u003eHistone H3 is a crucial component of chromatin structure and plays a pivotal role in gene regulation and DNA packaging. Phosphorylation of Histone H3 at Thr118 has been implicated in various cellular processes, including cell cycle progression, DNA repair, and transcriptional activation. Therefore, the ability to accurately detect and quantify phosphorylated Histone H3 at Thr118 is of utmost importance in understanding the underlying mechanisms of these biological processes.\u003cbr\u003e\u003cbr\u003eThe Histone H3(Phospho Thr118) Polyclonal Antibody offers outstanding performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated Histone H3 and other related proteins, ensuring reliable and specific results. \u003cbr\u003e\u003cbr\u003eWith its high sensitivity and specificity, this antibody enables researchers to explore the dynamic changes in Histone H3 phosphorylation at Thr118 in response to various stimuli or pathological conditions. Its versatility and robustness make it an indispensable tool for scientists working in the fields of epigenetics, chromatin biology, and cancer research.\u003cbr\u003e\u003cbr\u003eThe Histone H3(Phospho Thr118) Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and reproducibility. It is manufactured under stringent quality control standards to guarantee batch-to-batch consistency and optimal performance. \u003cbr\u003e\u003cbr\u003eIn summary, the Histone H3(Phospho Thr118) Polyclonal Antibody is a reliable and powerful tool for the detection and analysis of phosphorylated Histone H3 at Thr118 residue. Its exceptional sensitivity, specificity, and versatility make it an invaluable asset for researchers aiming to unravel the intricate mechanisms of chromatin biology and epigenetic regulation.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546314850584,"sku":"BT-AP10003","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_2bcc39af-0875-4304-88a9-eb3c0e9608ad.png?v=1705680180","url":"https:\/\/danabiosci.com\/products\/new-product-578546","provider":"Dana Bioscience","version":"1.0","type":"link"}