{"product_id":"new-product-578101","title":"ERK 8(Phospho Thr175\/Y177) Polyclonal Antibody","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation.,The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1.,In vitro, phosphorylates MBP.,PTM:Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.,PTM:Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase.,Belongs to the protein kinase superfamily. CMGC Ser\/Thr protein kinase family. MAP kinase subfamily.,Contains 1 protein kinase domain.,subunit:Interacts with CSK\/c-Src, ABL1, RET and TGFB1I1.,tissue specificity:Widely expressed with a maximal expression in lung and kidney.,\u003c\/p\u003e\n\u003cp\u003eThe ERK 8(Phospho Thr175\/Y177) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated ERK 8 protein. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eThe ERK 8(Phospho Thr175\/Y177) Polyclonal Antibody is raised in rabbits and purified using a combination of affinity chromatography and protein A\/G purification methods. This rigorous purification process guarantees a high level of purity and specificity, minimizing the risk of cross-reactivity with non-target proteins.\u003cbr\u003e\u003cbr\u003eThis antibody has been validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated ERK 8 protein in various biological samples.\u003cbr\u003e\u003cbr\u003eThe ERK 8(Phospho Thr175\/Y177) Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a 1 mg\/mL concentration, ensuring sufficient antibody for multiple experiments. The antibody is also available in different sizes to accommodate various experimental needs.\u003cbr\u003e\u003cbr\u003eWith its exceptional performance and reliability, the ERK 8(Phospho Thr175\/Y177) Polyclonal Antibody is an indispensable tool for researchers studying ERK 8 signaling pathways and its role in various biological processes. Its high specificity and sensitivity make it an ideal choice for accurate and precise detection of phosphorylated ERK 8 protein, facilitating further understanding of its function and potential therapeutic applications.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47546019643672,"sku":"BT-AP15462","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_63f54eb7-0696-4422-9ad9-1d0e1eb8b9f1.png?v=1705677637","url":"https:\/\/danabiosci.com\/products\/new-product-578101","provider":"Dana Bioscience","version":"1.0","type":"link"}