{"product_id":"new-product-577992","title":"E2F-1(Phospho Thr433) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.  This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media\u003c\/p\u003e\n\u003cp\u003eThe E2F-1(Phospho Thr433) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of E2F-1 protein phosphorylated at threonine 433 residue. This antibody has been meticulously developed using advanced techniques to ensure its superior performance in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.\u003cbr\u003e\u003cbr\u003eE2F-1 is a transcription factor that plays a crucial role in cell cycle regulation and is involved in the control of cell proliferation and apoptosis. Phosphorylation of E2F-1 at threonine 433 residue has been shown to modulate its activity and stability, making it an important target for research in the field of cell biology and cancer.\u003cbr\u003e\u003cbr\u003eThe E2F-1(Phospho Thr433) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of E2F-1, ensuring accurate and reliable results. It has been extensively validated using various cell lines and tissues, demonstrating its robust performance and reproducibility.\u003cbr\u003e\u003cbr\u003eThis antibody is produced using high-quality materials and follows stringent quality control measures to guarantee its consistency and reliability. It is supplied as a liquid formulation, ready for immediate use, and is available in various sizes to meet the specific needs of researchers.\u003cbr\u003e\u003cbr\u003eIn summary, the E2F-1(Phospho Thr433) Polyclonal Antibody is a valuable tool for investigating the phosphorylation status of E2F-1 at threonine 433 residue. Its exceptional specificity, sensitivity, and reliability make it an ideal choice for researchers in the field of cell biology and cancer research.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47545959186712,"sku":"BT-AP08684","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_1d79dfb6-5dc9-4c47-ad0f-a26c8d948613.png?v=1705677034","url":"https:\/\/danabiosci.com\/products\/new-product-577992","provider":"Dana Bioscience","version":"1.0","type":"link"}