{"product_id":"new-product-577946","title":"Doublecortin(Phospho-Ser378) Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (\"double cortex\" syndrome) in females and lissencephaly (\"smooth brain\u0026amp;quo\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe Doublecortin(Phospho-Ser378) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Doublecortin protein phosphorylated at Serine 378. This antibody is produced using advanced techniques to ensure exceptional quality and performance. Doublecortin is a protein that plays a crucial role in neuronal migration and differentiation during brain development. Phosphorylation of Doublecortin at Serine 378 has been implicated in regulating its function and cellular localization. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTherefore, the Doublecortin(Phospho-Ser378) Polyclonal Antibody is an invaluable resource for researchers studying neurodevelopmental processes and related disorders. This antibody exhibits excellent sensitivity and specificity, enabling accurate detection of Doublecortin phosphorylated at Serine 378 in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and shown to provide consistent and reproducible results. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe Doublecortin(Phospho-Ser378) Polyclonal Antibody is supplied as a liquid formulation, making it convenient and easy to use. It is provided in a vial with an optimized concentration, ensuring cost-effectiveness and minimizing wastage. With its exceptional performance and reliability, the Doublecortin(Phospho-Ser378) Polyclonal Antibody is an indispensable tool for researchers in the field of neuroscience and neurodevelopmental biology. It offers a comprehensive solution for investigating the role of Doublecortin phosphorylation in brain development and related pathologies.\u003c\/span\u003e\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47545935167768,"sku":"BT-AP15295","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_ff75b17a-e793-4b3d-8c0e-1c47fece49fe.png?v=1705676791","url":"https:\/\/danabiosci.com\/products\/new-product-577946","provider":"Dana Bioscience","version":"1.0","type":"link"}