{"product_id":"new-product-577874","title":"Dematin(Phospho Ser403) Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin\/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding di\u003c\/p\u003e\n\u003cp\u003eThe Dematin(Phospho Ser403) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Dematin protein phosphorylated at Ser403. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.\u003cbr\u003e\u003cbr\u003eDematin, also known as erythrocyte dematin or protein 4.9, is a cytoskeletal protein that plays a crucial role in maintaining the structural integrity and stability of the erythrocyte membrane. Phosphorylation of Dematin at Ser403 has been implicated in various cellular processes, including cell adhesion, migration, and signaling.\u003cbr\u003e\u003cbr\u003eThe Dematin(Phospho Ser403) Polyclonal Antibody exhibits exceptional specificity towards the phosphorylated form of Dematin at Ser403, enabling precise detection and quantification of this post-translational modification. It has been extensively validated in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThis antibody demonstrates high sensitivity, allowing for the detection of low levels of phosphorylated Dematin in complex biological samples. Its robust performance ensures accurate and reproducible results, making it an invaluable tool for researchers studying Dematin phosphorylation and its functional implications.\u003cbr\u003e\u003cbr\u003eThe Dematin(Phospho Ser403) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing waste. Each batch of antibody undergoes stringent quality control procedures to guarantee consistent performance and batch-to-batch reproducibility.\u003cbr\u003e\u003cbr\u003eIn summary, the Dematin(Phospho Ser403) Polyclonal Antibody is a reliable and specific tool for the detection and analysis of phosphorylated Dematin at Ser403. Its exceptional sensitivity, robust performance, and rigorous quality control measures make it an ideal choice for researchers investigating the role of Dematin phosphorylation in various cellular processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47545889718552,"sku":"BT-AP08446","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_48fda689-ae43-4ddc-b9ae-006e3c0ee3f3.png?v=1705676347","url":"https:\/\/danabiosci.com\/products\/new-product-577874","provider":"Dana Bioscience","version":"1.0","type":"link"}