CRLF2 Polyclonal Antibody

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

The CRLF2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of CRLF2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CRLF2 protein. The resulting polyclonal antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The CRLF2 Polyclonal Antibody is a valuable tool for researchers studying the role of CRLF2 in various biological processes, including hematopoiesis, immune response, and cancer. This antibody has been shown to detect endogenous levels of CRLF2 protein in various cell lines and tissues, making it an ideal choice for both basic research and clinical applications.

The CRLF2 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using a protein A column. This antibody is provided in a liquid format, making it easy to use in various applications. The antibody has been validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

Overall, the CRLF2 Polyclonal Antibody is a reliable and high-quality antibody that is ideal for researchers studying the role of CRLF2 in various biological processes. Its high specificity and sensitivity make it a valuable tool for both basic research and clinical applications.