Crk II(Phospho Tyr221) Polyclonal Antibody

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

The Crk II(Phospho Tyr221) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Crk II protein phosphorylated at tyrosine 221. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

Crk II is a crucial adaptor protein involved in various cellular processes, including cell adhesion, migration, and signaling. Phosphorylation of Crk II at tyrosine 221 plays a significant role in regulating its function and downstream signaling pathways. Therefore, the ability to detect and quantify this phosphorylation event is of utmost importance in understanding the molecular mechanisms underlying cellular processes.

The Crk II(Phospho Tyr221) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate detection and quantification of phosphorylated Crk II in various sample types, including cell lysates and tissue extracts. This antibody has been extensively validated through rigorous testing, ensuring reliable and reproducible results.

Furthermore, the Crk II(Phospho Tyr221) Polyclonal Antibody is compatible with a wide range of experimental techniques, including Western blotting, immunoprecipitation, and immunofluorescence. Its versatility allows researchers to explore the phosphorylation status of Crk II in different experimental settings, facilitating comprehensive investigations into its functional role.

In summary, the Crk II(Phospho Tyr221) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of phosphorylated Crk II at tyrosine 221. Its exceptional sensitivity, compatibility with various techniques, and extensive validation make it an invaluable asset for researchers studying cellular processes and signaling pathways involving Crk II.