CIC Polyclonal Antibody

The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes

The CIC Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of the CIC protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of the human CIC protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the CIC protein, making it an ideal tool for various research applications.

The CIC Polyclonal Antibody has been extensively validated for its performance in various immunoassays, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to detect endogenous levels of CIC protein in various human tissues and cell lines, with minimal cross-reactivity to other proteins. The antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography.

The CIC Polyclonal Antibody is a valuable tool for researchers studying the role of CIC protein in various biological processes, including cell proliferation, differentiation, and apoptosis. It can also be used for diagnostic purposes, such as the detection of CIC protein in cancer tissues. With its high specificity and sensitivity, this antibody is an essential reagent for any laboratory working in the field of molecular biology and immunology.