{"product_id":"new-product-577408","title":"CBLB Polyclonal Antibody","description":"\u003cp\u003eThe N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.,The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,The UBA domain interacts with poly-ubiquitinated proteins.,E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1\/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.,miscellaneous:This protein has one functional calcium-binding site.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28; which promotes proteasomal degradation.,PTM:Phosphorylated on tyrosine residues upon TCR or BCR activation, and upon various types of cell stimulation.,sequence Translated as Arg.,Contains 1 CBL N-terminal domain.,Contains 1 RING-type zinc finger.,Contains 1 SH2 domain.,Contains 1 UBA domain.,Contains 2 EF-hand-like domains.,subcellular location:Upon EGF stimulation, associates with endocytic vesicles.,subunit:Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May interact with CBL (By similarity). Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1\/CIN85. Identified in heterotrimeric complexes with SH3KBP1\/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin.,tissue specificity:Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level).,\u003c\/p\u003e\n\u003cp\u003eIntroducing the CBLB Polyclonal Antibody, a cutting-edge immunological tool designed to facilitate advanced research in the field of cellular biology. This high-quality antibody is meticulously developed using state-of-the-art techniques, ensuring exceptional specificity and sensitivity for the detection of CBLB protein expression.\u003cbr\u003e\u003cbr\u003eThe CBLB Polyclonal Antibody exhibits remarkable versatility, making it an invaluable asset for a wide range of applications. Its superior affinity enables precise identification and quantification of CBLB protein levels in various biological samples, including tissues, cells, and biofluids. This antibody's exceptional performance guarantees reliable and reproducible results, empowering researchers to delve deeper into the intricate mechanisms underlying cellular processes.\u003cbr\u003e\u003cbr\u003eCrafted with utmost precision, the CBLB Polyclonal Antibody boasts an exceptional signal-to-noise ratio, minimizing background interference and maximizing signal intensity. This attribute, coupled with its broad reactivity across multiple species, including human, mouse, and rat, ensures its suitability for diverse experimental settings.\u003cbr\u003e\u003cbr\u003eFurthermore, the CBLB Polyclonal Antibody is manufactured in strict adherence to rigorous quality control standards, guaranteeing batch-to-batch consistency and reliability. Its long shelf life and stability make it an ideal choice for long-term experiments, providing researchers with a dependable tool for their scientific endeavors.\u003cbr\u003e\u003cbr\u003eIn summary, the CBLB Polyclonal Antibody represents a breakthrough in immunological research, offering unparalleled specificity, sensitivity, and versatility. With its exceptional performance and reliability, this antibody is poised to revolutionize the field of cellular biology, enabling scientists to unravel the complexities of CBLB protein function and its implications in various physiological and pathological processes.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47545598771480,"sku":"BT-AP07183","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_24d0419c-7e73-4499-a361-ea64839ad42e.png?v=1705673851","url":"https:\/\/danabiosci.com\/products\/new-product-577408","provider":"Dana Bioscience","version":"1.0","type":"link"}