CAMLG Polyclonal Antibody

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

The CAMLG Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CAMLG protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CAMLG protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CAMLG protein, making it an ideal tool for various applications in research and diagnostics.

The CAMLG Polyclonal Antibody has been extensively validated for its performance in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been shown to detect CAMLG protein in a wide range of species, including human, mouse, rat, and others. The antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography.

The CAMLG Polyclonal Antibody is a valuable tool for researchers studying the role of CAMLG protein in various biological processes, including cell adhesion, migration, and signaling. It can also be used for the development of diagnostic assays for diseases associated with CAMLG protein dysregulation. The antibody is available in various sizes and formats to suit different experimental needs, and it is backed by our quality guarantee to ensure consistent and reliable results.