c-Myc(Phospho Thr358) Polyclonal Antibody

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

The c-Myc(Phospho Thr358) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated c-Myc at threonine 358 residue. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The c-Myc protein plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Phosphorylation of c-Myc at threonine 358 has been implicated in the regulation of its transcriptional activity and stability. Therefore, the ability to accurately detect and quantify phosphorylated c-Myc at this specific site is of utmost importance in understanding the intricate mechanisms underlying cellular signaling pathways.

This polyclonal antibody exhibits exceptional specificity towards phosphorylated c-Myc at threonine 358, enabling precise and reliable detection in various experimental settings. It has been extensively validated using a range of techniques, including Western blotting, immunohistochemistry, and immunofluorescence, ensuring its suitability for diverse applications.

The c-Myc(Phospho Thr358) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. Its high affinity and sensitivity allow for the detection of even low levels of phosphorylated c-Myc, facilitating accurate quantification and analysis.

With its exceptional performance and reliability, the c-Myc(Phospho Thr358) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the intricate mechanisms of cellular signaling pathways and their implications in various diseases and disorders.