AR Polyclonal Antibody

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform.

The AR Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of Androgen Receptor (AR) protein expression. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a region within the N-terminal domain of the human AR protein. It has been extensively validated for its specificity and affinity towards AR, ensuring reliable and accurate results in various applications.

The AR Polyclonal Antibody exhibits exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) techniques. It recognizes endogenous levels of AR protein in a variety of human tissues and cell lines, making it an ideal choice for both research and diagnostic purposes. With its high sensitivity, this antibody enables the detection of low levels of AR expression, facilitating the investigation of AR-related signaling pathways and cellular processes.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing waste. The AR Polyclonal Antibody is manufactured under strict quality control standards, guaranteeing batch-to-batch consistency and reproducibility.

In summary, the AR Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of AR protein expression. Its exceptional specificity, sensitivity, and versatility make it an indispensable asset for researchers and clinicians alike, enabling in-depth investigations into the role of AR in various physiological and pathological conditions.