{"product_id":"new-product-577132","title":"APTX Polyclonal Antibody","description":"\u003cp\u003eThis gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.\u003c\/p\u003e\n\u003cp\u003eThe APTX Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of APTX protein. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human APTX protein. The APTX Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe APTX protein is a DNA repair enzyme that plays a critical role in maintaining genomic stability. Mutations in the APTX gene have been associated with ataxia with oculomotor apraxia type 1 (AOA1), a rare autosomal recessive disorder characterized by progressive cerebellar ataxia, oculomotor apraxia, and peripheral neuropathy. The APTX Polyclonal Antibody can be used to study the expression and localization of APTX protein in normal and diseased tissues, as well as to investigate the molecular mechanisms underlying AOA1.\u003cbr\u003e\u003cbr\u003eThe APTX Polyclonal Antibody is supplied as a purified IgG fraction in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. The antibody has been affinity-purified using a column containing the immunizing peptide. The APTX Polyclonal Antibody is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. The recommended working dilution for Western blotting is 1:1000, while the recommended dilution for immunohistochemistry and immunofluorescence is 1:200.\u003cbr\u003e\u003cbr\u003eIn summary, the APTX Polyclonal Antibody is a highly specific and sensitive antibody that has been extensively validated for use in various applications. This antibody is an essential tool for researchers studying the role of APTX protein in DNA repair and the pathogenesis of AOA1.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47545425363224,"sku":"BT-AP14263","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_5425bb38-bd31-49fb-adc3-9f2300661a99.png?v=1705672317","url":"https:\/\/danabiosci.com\/products\/new-product-577132","provider":"Dana Bioscience","version":"1.0","type":"link"}