{"product_id":"new-product-577070","title":"ALS2 Polyclonal Antibody","description":"\u003cp\u003eThe protein encoded by this gene contains an ATS1\/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\u003cp\u003eThe ALS2 Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of ALS2 protein. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ALS2 protein. The ALS2 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.\u003cbr\u003e\u003cbr\u003eThe ALS2 Polyclonal Antibody is a valuable tool for researchers studying the function and regulation of ALS2 protein. ALS2 is a guanine nucleotide exchange factor that is involved in the regulation of small GTPases, which play important roles in various cellular processes, including vesicle trafficking, cytoskeletal organization, and signal transduction. Mutations in the ALS2 gene have been linked to several neurological disorders, including amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP).\u003cbr\u003e\u003cbr\u003eThe ALS2 Polyclonal Antibody has been shown to specifically recognize ALS2 protein in various human tissues and cell lines. This antibody has also been shown to detect endogenous ALS2 protein in mouse brain tissue. The ALS2 Polyclonal Antibody is highly sensitive, with a detection limit of 0.1 ng of ALS2 protein in Western blotting.\u003cbr\u003e\u003cbr\u003eIn summary, the ALS2 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of ALS2 protein in various applications. This antibody is a valuable tool for researchers studying the function and regulation of ALS2 protein, as well as the pathogenesis of neurological disorders associated with ALS2 mutations.\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47545386369304,"sku":"BT-AP06209","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_e8203fd2-6824-4f72-a53c-c7d6f4b29237.png?v=1705671949","url":"https:\/\/danabiosci.com\/products\/new-product-577070","provider":"Dana Bioscience","version":"1.0","type":"link"}