{"product_id":"new-product-576346","title":"TPOR(Phospho-Tyr626) Rabbit Polyclonal Antibody","description":"\u003cp\u003eIn 1990 an oncogene| v-mpl| was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue| named| c-mpl| was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl| thrombopoietin| was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene| CD110| is a 635 amino acid transmembrane domain| with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic| emphasizing the importantThe TPOR(Phospho-Tyr626) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of TPOR protein phosphorylated at tyrosine 626. This antibody has been rigorously validated for its specificity and performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe TPOR protein, also known as thrombopoietin receptor or MPL, plays a crucial role in the regulation of platelet production and megakaryocyte differentiation. Phosphorylation of TPOR at tyrosine 626 is a key event in the activation of downstream signaling pathways involved in these processes.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eThis rabbit polyclonal antibody has been developed using state-of-the-art techniques and high-quality reagents to ensure optimal performance and reproducibility. It exhibits a high affinity for TPOR phosphorylated at tyrosine 626, enabling accurate and reliable detection even at low expression levels.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe TPOR(Phospho-Tyr626) Rabbit Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It has been purified and concentrated to provide a high concentration of specific antibodies, minimizing background noise and maximizing signal intensity.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eWith its exceptional specificity and sensitivity, this antibody is an invaluable tool for researchers studying TPOR signaling pathways and its role in platelet production and megakaryocyte differentiation. It offers a reliable and reproducible means of investigating the phosphorylation status of TPOR at tyrosine 626, facilitating a deeper understanding of its functional significance.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eOrder the TPOR(Phospho-Tyr626) Rabbit Polyclonal Antibody today and unlock new insights into the intricate mechanisms underlying platelet production and megakaryocyte differentiation.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":47544914641176,"sku":"BT-AP13143","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/BT_Lab_79d57f26-8d1b-4a99-b754-d1040a14cac6.png?v=1705667795","url":"https:\/\/danabiosci.com\/products\/new-product-576346","provider":"Dana Bioscience","version":"1.0","type":"link"}